University of Pittsburgh Cancer Institute (UPCI)

Robert Edwards, MD

Robert Edwards
Executive Vice Chairman and Professor of Obstetrics, Gynecology & Reproductive Sciences
Co-Leader, Breast and Ovarian Cancer Program, UPCI
Co-Director, Women's Cancer Research Center, UPCI
Director, Transformational Medicine, UPMC

Contact Information

Contact Information

204 Craft Avenue
Pittsburgh, PA 15213

Phone: 412-641-8556
Email: redwards@mail.magee.edu
Fax: 412-641-8919

Administrative Assistant
Name: Judy Koryak
Phone: 412-641-5418
Email: koryakja@upmc.edu
Fax: 412-641-5417

Research Keywords

Research Keywords

Ovarian cancer; cervical cancer; gynecologic malignancies; intraperitoneal chemotherapy; immunotherapy; clinical trials

Research Summary

Research Summary

Dr. Edwards' research interests include cervical and ovarian malignancies. He serves as principle investigator of the Gynecologic Oncology Group for the University of Pittsburgh and for a number of pharmaceutical-sponsored studies. He also serves on the Cancer Vaccine Committee, which experiments with novel therapeutic approaches to gynecologic malignancies and produces translational research.

Three specific targets of Dr. Edwards’ research include: 1) vaccine therapies for cervical and ovarian cancer; 2) combining biologic and immunologic therapies with traditional therapies in the treatment of women’s cancer; and 3) intraperitoneal therapy.

Selected Publications

Selected Publications

  • Budiu RA, Elishaev E, Brozick J, Lee M, Edwards RP, Kalinski P, Vlad AM. Immunobiology of human mucin 1 in a preclinical ovarian tumor model. Oncogene. 2013 Aug 8;32(32):3664-75. PubMed Link
  • Skaznik-Wikiel ME, Lesnock JL, McBee WC, Beriwal S, Zorn KK, Richard SD, Krivak TC, Edwards RP. Intraperitoneal chemotherapy for recurrent epithelial ovarian cancer is feasible with high completion rates, low complications, and acceptable patient outcomes. Int J. Gynecol Cancer 2012 Feb;22(2):232-7. PubMed Link
  • Obermajer N., Muthuswamy, R., Odunsi K, Edwards RP, Kalinski P. PGE2-induced CXCL 12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment. Cancer Research. 2011 Dec. 15;71(24):7463-70. PubMed Link
  • Edwards, Robert P. Is hyperthermic intraoperative peritoneal chemotherapy and systemic chemotherapy as effective as standard intraperitoneal chemotherapy: time for a prospective trial? Lead Editorial on HIPEC: Gynecologic Oncology 2011 Aug 122(2):207-208. PubMed Link
  • Obermajer N, Muthuswamy R, Lesnock J, Edwards RP, Kalinski P. Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells. Blood. 2011 Nov 17;118(20):5498-505. PubMed Link
  • Budiu RA, Mantia-Smaldone G. Elishaev E, Chu T, Thalle J McCabe K, Lenzner D, Edwards RP, Vlad AM. Soluble MUC1 and serum MUC1-specific antibodies are potential prognostic biomarkers for platinum-resistant ovarian cancer. Cancer Immunol Immunother. 2011 Jul;60(7):975-84. PubMed Link
  • Vlad AM, Budiu RA, Lenzner DE, Wang Y, Thaller JA, Colonello K, Crowley-Nowick PA, Kelley JL, Price FV, Edwards RP. A phase II trial of intraperitoneal interleukin-2 in patients with platinum-resistant or platinum-refractory ovarian cancer. Cancer Immunol Immunother. 2010 Feb;59(2):293-301. (Cited in Nature Cancer Reviews March 2010). PubMed Link
  • Helm CW, Randall-Whitis L, Martin RS III, Metzinger DS, Gordinier ME, Parker LP, Edwards RP. Hyperthermic intraperitoneal chemotherapy in conjunction with surgery for the treatment of recurrent ovarian carcinoma. Gynecol Oncol, 2007 Apr;105(1):90-6. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current UPCI/Pitt Collaborators

David Bartlett, MD
Dr. Bernard Fisher Professor of Surgery and Chief of Surgical Oncology
Member - Cancer Immunology Program (CIP)

Xin Huang, PhD
Assistant Professor of Obstetrics, Gynecology & Reproductive Sciences
Member - Breast and Ovarian Cancer Program (BOCP)

Rebecca Jacobson, MD, MS
Professor of Biomedical Informatics
Member - Cancer Therapeutics Program (CTP)

Pawel Kalinski, MD, PhD
Associate Professor of Surgery and Immunology
Member - Cancer Immunology Program (CIP)

Faina Linkov, PhD, MPH
Research Assistant Professor of Medicine
Member - Biobehavioral Oncology Program (BOP)

Frances Modugno, PhD, MPH
Associate Professor, Department of Obstetrics, Gynecology & Reproductive Sciences

Steffi Oesterreich, PhD
Professor of Pharmacology & Chemical Biology
Member - Breast and Ovarian Cancer Program (BOCP)

Anda Vlad, MD, PhD
Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Department of Immunology
Member - Breast and Ovarian Cancer Program (BOCP)

Current External Collaborators

Kirsten Moysich, PhD, MS
Professor of Oncology, Department of Cancer Prevention and Control
Roswell Park Cancer Institute

Kunle Odunsi, MD, PhD, FRCOG, FA
Chair, Department of Gynecologic Oncology
Roswell Park Cancer Institute

UPCI Shared Resource Usage

UPCI Shared Resource Usage

  • Biostatistics Facility
  • Cancer Bioinformatics Services
  • IMCPL
  • Investigational Drug Services
  • Tissue and Research Pathology Services








Last modified: 10/16/14