University of Pittsburgh Cancer Institute (UPCI)

Agenda

6:30 a.m. Mito FunRun
7:30 a.m. Continental Breakfast
8:30 a.m. Opening Remarks and Introductions: Chi Van Dang, MD, PhD
8:45 a.m. Keynote Address 1: Nick Lane, PhD, “Mitochondria – Key to Complex Life”
9:30 a.m. Session I: “Cancer Metabolism” – Chair: Celeste Simon, PhD
9:30 a.m. Celeste Simon, PhD“Hypoxia, Metabolism, and Tumor Progression”
9:55 a.m. Kathryn Wellen, PhD“Links Between Cancer Cell Metabolism and Epigenetics”
10:20 a.m. Manti Guha, PhD“Reduction in mtDNA Copy Number Generates Cancer Stem Cells and Induces Epithelial-Mesenchymal Transition in Human Mammary Epithelial Cells”

10:35 a.m. Break
10:50 a.m. Session II: “Mitochondrial Medicine” – Chair: Lance Becker, MD
10:50 a.m. Lance Becker, MD“The Importance and Opportunities for Reversal of Mitochondrial Dysfunction in Acute Critical Illness”
11:15 a.m. Marni Falk, MD, PhD“Pharmacologic Inhibition of Cystosolic Translation Offers a Novel Therapeutic Approach for Mitochondrial Respiratory Chain Disease”
11:40 a.m. Morten Scheibye-Knudsen, MD“Defective Mitophagy in Xeroderma Pigmentosum Group A via PARP1 Activation and Impairment of the NAD+/SIRT1 Pathway”

12:00 p.m. Lunch and Poster Viewing (Box Lunch Provided)
1:30 p.m. Session III: “Neurodegeneration & Metabolism” – Chair: Emiliana Borrelli, PhD
1:30 p.m. Emiliana Barrelli, PhD“Neuronal Mitochondrial Dynamics: Metabolism, Regulation, and Relevance to Parkinson’s Disease Models”
1:55 p.m. Sarah Berman, MD, PhD“Neuronal mitochondrial dynamics: metabolism, regulation, and relevance to Parkinson’s disease models”
2:20 p.m. Nagendra Yadava, PhD“Metabolic Consequences of the Partial Complex I Deficiency in an X-Chromosome-Linked Mouse Model”

2:35 p.m. Break
2:50 p.m. Session IV: “Mitochondrial Biophysics” – Chair: Tomoko Ohnishi, PhD
2:50 p.m. Tomoko Ohnishi, PhD“Involvement of Two Distinct Protein-Associated Ubiquinone Molecules in the Proton-Pumping Mechanism in Complex I”
3:15 p.m. György Hajnóczky, MD, PhD“Local Signaling Between Mitochondria and ER”
3:40 p.m. Kevin Foskett, PhD“Essential Regulation of Cell Bioenergetics by Constitutive ER Ca2+ Transfer to Mitochondria”

4:05 p.m. Poster Judging Session
4:45 p.m. Keynote Address 2: Paolo Sassone-Corsi, PhD“Epigenetics, Metabolism and the Circadian Clock”
5:30 p.m. Closing Remarks & Poster Award Ceremony: Douglas C. Wallace, PhD
5:45 p.m. Reception
6:30 p.m. Meeting Adjourned