The mission of the Surgical Oncology Disease Site is to provide state-of-the-art, specialized and individualized surgical care to patients with cancer. Surgeons partner extensively with UPCI medical oncologists to provide patients with the latest combined therapies, including neoadjuvant therapies, as well as treatments for advanced disease such as intraoperative delivery of biological therapies, chemoembolization for liver metastases, or intraoperative hyperthermic chemotherapy for advanced abdominal malignancies. These combinations are aimed at achieving maximal tumor destruction while preserving organ function. Novel and promising biological therapies developed by basic research faculty within the Surgical Oncology Disease Site are translated into clinical trials, providing innovative treatment options for patients suffering from advanced disease.