University of Pittsburgh Cancer Institute (UPCI)
Award Programs
The Lung Cancer SPORE announces the following award recipients for year seven of the grant:
Developmental Research Program Awards
- Awardee: Richard Steinman, MD, PhD
Decoding Temptation: How Lung Cancer Cells Seduce Normal Cells to Become Accomplices to Invasion - Awardee: Steven D. Shapiro MD
Impact of Cigarette Smoke-induced Emphysema on Lung Tumorigenesis
Career Development Award Program
- Awardee: Robert Binder, PhD
Alpha2-macroglobulin based vaccines for lung cancer - Awardee: A. McGarry Houghton, MD
Impact of Inflammatory Cell Subsets and Proteinases on Outcomes in Human Lung Adenocarcinoma and Squamous Cell Carcinoma - Awardee: Ann Marie Egloff, PhD, MPH
Evaluating Polymorphisms in EGFR-GRPR Signaling Axis Components for Association with Lung Cancer Risk in Never Smokers and Former Smokers - Awardee: Christopher Bakkenist, PhD
Targeting ATM- and FANC-deficient Lung Cancers with Inhibitors of DNA Repair Pathways - Awardee: Brenda Diergaarde, PhD
Polymorphisms in Inflammation-Related Genes and Risk of Smoking-Associated Lung Cancer and COPD - Awardee: Pamela Hershberger, PhD
Laboratory Correlative Studies to Support Early-Phase Clinical Trials of Targeted Agents in Lung Cancer
Proposal Solicitation – Developmental Research Projects in Lung Cancer
Sponsored by:
The Specialized Program of Research Excellence (SPORE) in Lung Cancer
University of Pittsburgh Cancer Institute
Suggested Area of Interest: Inflammation and Lung Cancer
The Lung Cancer SPORE of the UPCI announces a program to encourage developmental research in the relationship between lung inflammation and lung cancer. The Developmental Research Program consists of available funding, blood, tissue and cell repository, and a group of SPORE investigators to provide guidance and collaboration in the development of projects. The Core Laboratories of the Lung Cancer SPORE Program (Tissue & Blood Bank, Clinical Core, and Biostatistics/Bioinformatics) are available to investigators funded through the Developmental Research Program. These SPORE resources now also include an expanded repository of blood specimens from high-risk subjects recruited in our ongoing project in early detection of lung cancer by CT screening, and newly developed lung tissue microarrays. The support of pilot projects is available on a competitive basis to all faculty members of UPCI. Other areas of interest will be considered.
Application Components and Instructions
- Download application (.doc format, 50k)
The application will include the following (submit all documents electronically to M. Linda Gangewere, Lung SPORE Administrator at gangewerel@upmc.edu:
- Application cover page;
- NIH Biosketch (Form SR424 (R&R) detailing previous training, relevant experience, and bibliography;
- Five-page research plan for the proposed research project, including methodology;
- Translational impact statement;
- Budget (Form SR424 (R&R);
- Budget justification statement.
Applications will be reviewed by the Developmental Research Program Standing Committee. Recipients may be awarded funds up to a total of $35,000 per year to be applied over a one or two year grant period ($70,000 maximum). Since funds are limited, all expenditures must be carefully justified. Approved applications will be funded beginning April 1, 2009. Applicants for multiyear awards must show progress and participate in SPORE Program activities to obtain funds for the second year.
Suggested Area of Research Interest for This Announcement
The Lung Cancer SPORE is interested in funding research proposals that will address the interaction between lung inflammation and lung cancer. Aspects of particular interest are: genetic susceptibility to both lung inflammatory conditions and lung cancer, genomics applied to both diseases, animal models of lung cancer development in the context of lung inflammatory conditions, molecular pathways that interact in both diseases, and role of inflammatory cytokines in lung cancer. Proposals addressing other areas of research interest also will be considered.
Successful applicants will be expected to participate in the Lung Cancer SPORE Investigators’ monthly meetings and to present the progress of their projects to this group during the course of the grant. Applicants wishing more specific information about the SPORE projects and cores, including availability of lung tissues and blood specimens already collected by the Tissue & Blood Bank, should contact Dr. Siegfried at the address below.
Information on the projects and cores of the SPORE in Lung Cancer is available at http://www.upci.upmc.edu/spore/lung/index.cfm.
Subsequent Extramural Support
It is anticipated that these pilot projects should result in the collection of sufficient preliminary data to obtain extramural support for the project, either through the SPORE mechanism or through individual grants. The Lung Cancer SPORE is also interested in promoting multi-disciplinary grant submissions, such as P01’s, among its members.
Proposal Submissions
Proposals should be sent as a Word document in electronic format to M. Linda Gangewere, Lung SPORE Administrator, at gangewerel@upmc.edu; telephone: 412-623-7770. Please see the application cover page (attachment 2) for full instructions. The deadline for receipt of applications is February 27, 2009.
Scientific questions can be addressed to Jill M. Siegfried, Ph.D., Principal Investigator, UPCI SPORE in Lung Cancer, siegfriedjm@upmc.edu; telephone: 412-623-7769 or 412-648-1942.
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