Chemical Diversity
Molecular Targets
Pharmacokinetics and Pharmacodynamics
Clinical TrialsClinical Trials
Clinical investigators in the MTDDP design and perform Phase I, Phase I/II, and Phase II studies of small molecule anticancer agents, either alone or in combination with other drugs.
Selected Publications
- Irinotecan and weekly cetuximab (I+C) is a standard second-line regimen for metastatic colorectal cancer (mCRC). Patients with mCRC refractory to first-line fluoropyrimidine/oxaliplatin regimens and not previously treated with I+C were treated every 2 weeks with I+C. No efficacy of this combination was demonstrated at the dose and schedule tested (Carneiro BA et. al. Clin Colorectal Cancer. 11:53-9, 2012).
- The addition of bevacizumab to paclitaxel improved progression-free survival of patients with metastatic breast cancer. In a phase II clinical trial, MTDDP investigators examined the efficacy and safety of adding gemcitabine to paclitaxel/bevacizumab. Although this triple drug regimen generally was well tolerated, it did not improve the overall response rate (Brufsky A et. al. Clin Breast Cancer 11:211-20, 2011).
- MTTDP participated in a phase III clinical study that compared the efficacy and safety of bevacizumab combined with standard chemotherapy regimens versus chemotherapy alone as second-line treatment of patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. The combination of bevacizumab with commonly used chemotherapies improved progression-free survival in the second-line treatment of patients with HER2-negative metastatic breast cancer, with a safety profile comparable with that in prior phase III studies (Brufsky AM et. al. J Clin Oncol 29:4286-93, 2011).
Members
| Appleman, Leonard, MD, PhD Medicine |
Maranchie, Jodi, MD, FACS Urology |
| Bahary, Nathan, MD, PhD Medicine |
Pollack, Ian, MD Neurological Surgery |
| Bartlett, David, MD Surgery |
Puhalla, Shannon, MD Medicine |
| Brufsky, Adam, MD, PhD Medicine |
Ragni, Margaret, MD, MPH Medicine |
| Edwards, Robert, MD Obstetrics, Gynecology & Reproductive Sciences |
Redner, Robert, MD Medicine |
| Gnarra, James, PhD Urology |
Ritchey, A. Kim, MD Pediatrics (CHP) |
| Goyal, Rakesh, MD Pediatrics (CHP) |
Schoen, Robert, MD, MPH Medicine |
| Greenspan, Susan, MD Medicine |
Stoller, Ronald, MD Medicine |
| He, Qiuhong, PhD Radiology |
Tawbi, Hussein, MD Medicine |
| Jakacki, Regina, MD Pediatrics (CHP) |
Virji, Mohamed, MD, PhD Pathology |
| Kelley, Joseph, MD Obstetrics, Gynecology & Reproductive Sciences |
Zeh, Herbert, MD Surgery |
| Krishnamurti, Lakshmanan, MD Pediatrics (CHP) |
Zorn, Kristin, MD Obstetrics, Gynecology & Reproductive Sciences |
| Krivak, Thomas, MD Obstetrics, Gynecology & Reproductive Sciences |
