University of Pittsburgh Cancer Institute (UPCI)

Program Members

Bennett Van Houten, PhD Bennett Van Houten, PhD (Co-Leader)
Email: vanhoutenb@upmc.edu
Research Keywords:
DNA repair; cancer pharmacology; drug discovery

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Zhou Wang, PhD Zhou Wang, PhD (Co-Leader)
Email: wangz2@upmc.edu
Research Keywords:
Androgen receptor; prostate cancer; tumor suppressors; intermittent androgen deprivation therapy; U19/EAF2

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Karen Arndt, PhD Karen Arndt, PhD
Email: arndt@pitt.edu
Research Keywords:
Transcriptional control

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Ivet Bahar, PhD Ivet Bahar, PhD
Email: bahar@pitt.edu
Research Keywords:
Biomolecular systems dynamics at multiple scales; evolution of proteins' sequence, structure, dynamics and function; computer-aided drug discovery and polypharmacology; network models for protein-protein interactions, supramolecular machinery and allostery; modeling and simulations of membrane protein dynamics and mechanisms of interactions

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Mingfeng Bai, PhD Mingfeng Bai, PhD
Email: baim@upmc.edu
Research Keywords:
Molecular imaging; contrast agents; CB2 receptor; near infrared; fluorescence dye; optical imaging; phototherapy; fluorescence imaging; NIR dye; imaging probe; in vivo imaging; fluorescence microscopy; cancer treatment; photodynamic therapy

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Christopher Bakkenist, PhD Christopher Bakkenist, PhD
Email: bakkenistcj@upmc.edu
Research Keywords:
Cancer pharmacology; DNA repair

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Donna Beer Stolz, PhD Donna Beer Stolz, PhD
Email: dstolz@pitt.edu
Research Keywords:
Growth factor signaling; angiogenesis; liver regeneration and transplantation

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Takis Benos, PhD Takis Benos, PhD
Email: benos@hgen.pitt.edu
Research Keywords:
Computational genomics; systems biology

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Kara Bernstein, PhD Kara Bernstein, PhD
Email: bernsteink@upmc.edu
Research Keywords:
DNA repair; DNA recombination; double-strand break repair; gross chromosomal rearrangements; RecQ DNA helicases; Rad51 paralogues

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Jeffrey Brodsky, PhD Jeffrey Brodsky, PhD
Email: jbrodsky@pitt.edu
Research Keywords:
Protein quality control

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Marcel Bruchez, PhD Marcel Bruchez, PhD
Email: bruchez@cmu.edu
Research Keywords:
Fluorescence; biological microscopy; imaging; light-harvesting structures; biosensors; single molecule biophysics; protein translation; protein folding; protein trafficking

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J. Richard Chaillet, MD, PhD J. Richard Chaillet, MD, PhD
Email: chaillet@pitt.edu
Research Keywords:
Genomic imprinting; epigenetic inheritance; embryonic stem cells; DNA methylation

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Marie C. DeFrances, MD, PhD Marie C. DeFrances, MD, PhD
Email: defrancesmc@upmc.edu
Research Keywords:
PI3-kinase signaling

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Donald B. DeFranco, PhD Donald B. DeFranco, PhD
Email: dod1@pitt.edu
Research Keywords:
Receptor pharmacology; neuropharmacology; signal transduction

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Andrew Duncan, PhD Andrew Duncan, PhD
Email: duncana@pitt.edu
Research Keywords:
Hepatocellular carcinoma; liver cancer; liver development; liver homeostasis; liver regeneration; genetic diversity; cell cycle regulation; hepatic aneuploidy; hepatic polyploidy

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Farzad Esni, PhD Farzad Esni, PhD
Email: Farzad.Esni@chp.edu
Research Keywords:
Genetics of pancreatic cancer; hypoxia

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Ferruccio Galbiati, PhD Ferruccio Galbiati, PhD
Email: feg5@pitt.edu
Research Keywords:
Caveolin; senescence; oxidative stress; cancer; aging; age-related disease

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Deborah L. Galson, PhD Deborah L. Galson, PhD
Email: galson@pitt.edu
Research Keywords:
Multiple myeloma; breast cancer; cancer-induced bone disease; signal transduction; epigenetic regulation; transcription factors; bone biology; Paget's disease

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Madhavi Ganapathiraju, PhD Madhavi Ganapathiraju, PhD
Email: madhavi+upci@pitt.edu
Research Keywords:
Systematic discovery of protein-protein interactions; host-pathogen systems biology

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Yang Hong, PhD Yang Hong, PhD
Email: yhong@pitt.edu
Research Keywords:
Cell polarity; genetics

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Johnny Huard, PhD Johnny Huard, PhD
Email: jhuard@pitt.edu
Research Keywords:
Stem cells; gene therapy

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William A. LaFramboise, PhD William A. LaFramboise, PhD
Email: laframboisewa@upmc.edu
Research Keywords:
Clinical genomics; next generation sequencing; targeted deep sequencing; cancer stem cells

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Li Lan, MD, PhD Li Lan, MD, PhD
Email: lanl@upmc.edu
Research Keywords:
DNA damage response; oxidative DNA damage; KillerRed; imaging; genome stability; chromatin remodeling; epigenetics; histone

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Byeong-Chel Lee, PhD Byeong-Chel Lee, PhD
Email: leeb4@upmc.edu
Research Keywords:
Molecular mechanisms of hematopoietic stem cell senescence; breast cancer cell metastasis

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Yong J. Lee, PhD Yong J. Lee, PhD
Email: leeyj@upmc.edu
Research Keywords:
Colorectal cancer; TRAIL; chemotherapeutic agents; hyperthermia; NK cells

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Yang Liu, PhD Yang Liu, PhD
Email: liuy10@upmc.edu
Research Keywords:
Biomedical optical imaging and spectroscopy; early cancer diagnosis, surveillance and prevention

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Joseph Locker, MD, PhD Joseph Locker, MD, PhD
Email: lockerj@upmc.edu
Research Keywords:
Molecular biology; hepatocytes; carcinogenesis; tumorigenesis; cell proliferation; hepatocellular carcinoma; liver cancer; lung cancer; transcription factors; transcriptional regulation; stem cells; progenitor cells; molecular diagnostics

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Xinghua Lu, MD, PhD Xinghua Lu, MD, PhD
Email: xil86@pitt.edu
Research Keywords:
Systems biology approaches to modeling cellular signal transduction pathways based on multiple sources of "omics" scale data, and their application in cancer

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Peter Lucas, MD, PhD Peter Lucas, MD, PhD
Email: lucaspc@upmc.edu
Research Keywords:
Chronic inflammation; NF-kB; signal transduction; carcinogenesis

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Jianhua Luo, MD, PhD Jianhua Luo, MD, PhD
Email: luoj@upmc.edu
Research Keywords:
Prostate cancer gene expression; invasion and metastasis

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Linda M. McAllister-Lucas, MD, PhD Linda M. McAllister-Lucas, MD, PhD
Email: lmm180@pitt.edu
Research Keywords:
Signal transduction; inflammation; G protein-coupled receptor (GPCR); NF-kB; oncogenesis

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George K. Michalopoulos, MD, PhD George K. Michalopoulos, MD, PhD
Email: michalopoulosgk@upmc.edu
Research Keywords:
Growth factors and receptors in hepatocytes; growth regulation of human hepatocytes; hepatic carcinogenesis

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Satdarshan (Paul) Monga, MD Satdarshan (Paul) Monga, MD
Email: smonga@pitt.edu
Research Keywords:
Signal transduction; Wnt/beta-catenin; HGF/Met; EGF; PDGF; growth factors; liver development; hepatic physiology; liver disease; liver cancer; hepatocellular carcinoma

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Joel Nelson, MD Joel Nelson, MD
Email: nelsonjb@upmc.edu
Research Keywords:
Prostate cancer; urinary tract malignancies; hormone refractory cancer; surgical oncology; clinical trials; edothelin-1; bone metastasis; androgen independent prostate cancer

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Roderick (Roddy) J. O'Sullivan, PhD Roderick (Roddy) J. O'Sullivan, PhD
Email: osullivanr@upmc.edu
Research Keywords:
Structural and epigenetic functions of human telomeres; aging and cancer

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Patricia Opresko, PhD Patricia Opresko, PhD
Email: popresko@eoh.pitt.edu
Research Keywords:
Cancer and aging; DNA damage, repair, and replication; DNA helicases; Werner syndrome; telomeres and telomere-binding proteins; DNA polymerases; mutagenesis

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Hongjiao Ouyang, DDS, PhD, DMD Hongjiao Ouyang, DDS, PhD, DMD
Email: hoo1@pitt.edu
Research Keywords:
Cellular and molecular mechanisms underlying bone development, maintenance, and disease

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Bruce Pitt, PhD Bruce Pitt, PhD
Email: brucep@pitt.edu
Research Keywords:
Molecular and cellular biology of the lung; gene therapy

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Edward V. Prochownik, MD, PhD Edward V. Prochownik, MD, PhD
Email: prochownikev@upmc.edu
Research Keywords:
c-Myc, glycolysis, oxidative phosphorylation, mitochondria, metabolism, TCA cycle, electron transport chain

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Gerald P. Schatten, PhD Gerald P. Schatten, PhD
Email: gschatten@pdc.magee.edu
Research Keywords:
Stem cells; gene therapy; human reproduction and development; breast and ovarian cancers

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Martin Schmidt, PhD Martin Schmidt, PhD
Email: mcs2@pitt.edu
Research Keywords:
Cellular metabolism; signal transduction pathways

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Robert W. Sobol, PhD Robert W. Sobol, PhD
Email: rws9@pitt.edu
Research Keywords:
DNA repair; cancer pharmacology; drug discovery; base excision repair; poly-ADP ribose; lentivirus

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Daolin Tang, MD, PhD Daolin Tang, MD, PhD
Email: tangd2@upmc.edu
Research Keywords:
Role of HMGB1 in autophagy, apoptosis, and cancer

Gary Thomas, PhD Gary Thomas, PhD
Email: thomasg@pitt.edu
Research Keywords:
Signal transduction; cell membrane traffic; cancer biology; viral pathogenesis

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George C. Tseng, ScD George C. Tseng, ScD
Email: ctseng@pitt.edu
Research Keywords:
Statistical applications of genomics and bioinformatics

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Yong Wan, PhD Yong Wan, PhD
Email: yow4@pitt.edu
Research Keywords:
Regulation of intracellular signaling and gene expression; DNA repair; cell cycle control

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Hong Wang, PhD Hong Wang, PhD
Email: how8@pitt.edu
Research Keywords:
Survival analysis and statistics in cancer biomarker research; radiation survival analysis

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Simon C. Watkins, PhD Simon C. Watkins, PhD
Email: swatkins+@pitt.edu
Research Keywords:
Cellular organization; cell-cell communications; cell imaging

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Kurt R. Weiss, MD Kurt R. Weiss, MD
Email: weiskr@UPMC.EDU
Research Keywords:
Musculoskeletal oncology; cancer stem cells

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John L. Woolford, Jr., PhD John L. Woolford, Jr., PhD
Email: jw17+@andrew.cmu.edu
Research Keywords:
Assembly of ribosomes in eukaryotes

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Cary Wu, PhD Cary Wu, PhD
Email: carywu@pitt.edu
Research Keywords:
Cell-matrix adhesion; signal transduction

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Nathan Yates, PhD Nathan Yates, PhD
Email: yatesn@pitt.edu
Research Keywords:
Mass spectrometry; proteomics

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Jian Yu, PhD Jian Yu, PhD
Email: yuj2@upmc.edu
Research Keywords:
Apoptosis regulation and the role of the Bcl-2 protein family in cancer biology and therapy

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Reza Zarnegar, PhD Reza Zarnegar, PhD
Email: rezazar@pitt.edu
Research Keywords:
Hepatocyte Growth Factor (HGF); physiological and pathological role of the HGF/Met axis in normal tissue homeostasis and disease processes including cancer

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Lin Zhang, PhD Lin Zhang, PhD
Email: zhanglx@upmc.edu
Research Keywords:
Protein kinases and phosphatases; cancer pharmacology

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