Overview
The purpose of translational research is to translate basic scientific discoveries into clinical applications, thereby generating clinical observations needed to give focus to basic research. In so doing, translational research integrates lab activities from bench to bedside. The mission of Spang Translational Research Facility (TRF) is to provide this much needed bridge of communication between highly specialized research scientists and physicians. It is vital that cutting edge research be available to physicians in a useable format, and, likewise, that information gathered by physicians is available to researchers. The main function of TRF is to conduct state-of-the-art laboratory-based research on human samples for UPCI investigators from IRB approved clinical trials.
The Facility will provide expertise and instrumentation to UPCI for signal transduction pathways in both clinical and pharmaceutical research. The currently available techniques include measurement of activation status of kinases and transcription factor DNA binding.
Functions of TRF:
- To facilitate laboratory-based research on human samples from IRB-approved clinical trials.
- To provide laboratory infrastructure to UPCI investigators interested in generating preliminary pre-clinical data in support of the hypotheses to be tested in clinical trials (e.g. evidence of drug synergy, biomarker(s) for target inhibition or response to treatment).
- To support UPCI investigators involved in translational research.