University of Pittsburgh Cancer Institute (UPCI)

AIDS-related and Other Immunodeficiency Malignancies (ARM)

Kaposi's sarcomaAIDS-related cancers are now the most common malignancies in sub-Saharan Africa. UPCI is one of the leading centers for AIDS-related malignancy research. The University of Pittsburgh and UPCI have developed a strategic goal to enhance research activities in international settings, and the expertise of the CVP ARM will be an important contributor to this goal.

Human immunodeficiency virus (HIV) itself is classified as an infectious carcinogen by WHO International Agency for Research on Cancer (IARC), primarily due to its capacity to increase risk for opportunistic cancers. The CVP ARM has a strong component investigating the mechanisms for HIV-related immunodeficiency and pathogenesis. Immunosuppressed transplant patients also face many of the same cancer issues as AIDS patients. Members of the ARM investigate the role of immunosuppression in virus-induced tumors and have initiated productive collaborations with the University of Pittsburgh transplantation community on topics such as post-transplant lymphoproliferative disorder (PTLD) pathogenesis and immunity, and KSHV diagnostics for transplantation screening. Additionally, mucosal infection with oncogenic human papillomavirus (HPV) and its link to both dysplasia and malignancy is being investigated in a population of iatrogenically immunosuppressed patients with inflammatory bowel disease.

Selected Publications

Members

Section Leader: Ross Cranston

Chang, Yuan, MD
Pathology
Moore, Patrick MD, MPH
Microbiology and Molecular Genetics
Cranston, Ross, MD
Medicine
Pantanowitz, Liron, MD
Pathology
Gupta, Phalguni, PhD
Infectious Diseases & Microbiology
Reinhart, Todd, ScD
Infectious Diseases & Microbiology
Montelaro, Ronald, PhD
Microbiology and Molecular Genetics
Rinaldo, Charles, PhD
Pathology