University of Pittsburgh Cancer Institute (UPCI)

Program Members

Edward Chu, MD Edward Chu, MD (Co-Leader)
Email: chue2@upmc.edu
Research Keywords:
Cancer pharmacology; cancer drug development; phase I/II clinical trials; drug resistance; regulation of gene expression; translational regulation; Chinese herbal medicine; colorectal cancer; GI cancers

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Peter Wipf, PhD Peter Wipf, PhD (Co-Leader)
Email: pwipf@pitt.edu
Research Keywords:
Anti-cancer therapeutics; drug discovery; anti-inflammatory agents; heterocyclic chemistry; kinase inhibitors; medicinal chemistry; mitochondrial targeting; natural products; organic synthesis; radiation dermatitis; radiation mitigation; radiation protection; reactive oxygen species scavengers; toll-like receptors

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Nduka Amankulor, MD Nduka Amankulor, MD
Email: nma40@pitt.edu
Research Keywords:
Microenvironment and immune escape in glioblastoma; oligodendroglioma; brain and spine metastases

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Leonard J. Appleman, MD, PhD Leonard J. Appleman, MD, PhD
Email: applemanlj@upmc.edu
Research Keywords:
Kidney cancer and other genitourinary malignancies; experimental cancer therapeutics

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Nathan Bahary, MD, PhD Nathan Bahary, MD, PhD
Email: baharyn@upmc.edu
Research Keywords:
Novel treatment strategies for GI cancers; developmental biology using the zebrafish model system; vasculogenesis; hematopoiesis

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Jan-Hendrik Beumer, PharmD, PhD Jan-Hendrik Beumer, PharmD, PhD
Email: beumerjh@upmc.edu
Research Keywords:
Pharmacokinetics and metabolism of anti-cancer drugs; nucleoside analogues and epigenetic drugs

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Michael Boyiadzis, MD Michael Boyiadzis, MD
Email: boyiadzism@upmc.edu
Research Keywords:
Hematological malignancies

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Dev Chakraborty, PhD Dev Chakraborty, PhD
Email: dpc10@pitt.edu
Research Keywords:
Observer performance; ROC; FROC; statistical modeling of radiologist interpretations; data analysis; simulations; computer aided diagnosis (CAD) algorithms

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Dennis Curran, PhD Dennis Curran, PhD
Email: curran@pitt.edu
Research Keywords:
Natural products total synthesis; new synthetic methods; stereochemistry

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Alexander Deiters, PhD Alexander Deiters, PhD
Email: deiters@pitt.edu
Research Keywords:
Chemical biology; medicinal chemistry; synthetic chemistry; synthetic biology; microRNA; miRNA; optogenetics; photobiology; photochemistry; oligonucleotide; nucleic acid; amino acid; protein engineering; imaging

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Jan Drappatz, MD Jan Drappatz, MD
Email: drappatzj@upmc.edu
Research Keywords:
CNS tumors; brain tumors; glioma; glioblastoma; angiogenesis inhibitors; targeted therapies; immunotherapy; neurologic complications of cancer; prognostic biomarkers

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Anette Duensing, MD Anette Duensing, MD
Email: aduensin@pitt.edu
Research Keywords:
Gastrointestinal stromal tumor; GIST; targeted therapies; Gleevec; sarcoma

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Julie Eiseman, PhD Julie Eiseman, PhD
Email: eisemanj@upmc.edu
Research Keywords:
Preclinical drug development; toxicology; pharmacokinetics; efficacy

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Johnathan Engh, MD Johnathan Engh, MD
Email: enghja@upmc.edu
Research Keywords:
Brain tumor; spine tumor; endoport; flexible needle; glioblastoma; oligodendroglioma; colloid cyst; chiari malformation

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Bruce Freeman, PhD Bruce Freeman, PhD
Email: freerad@pitt.edu
Research Keywords:
Inflammation; cell proliferation; redox signaling; free radical; nitric oxide; lipid signaling; pharmacology; drug discovery

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H. Michael Gach, PhD H. Michael Gach, PhD
Email: gachh@upmc.edu
Research Keywords:
Medical imaging; function MRI; targeted radiotracers; PET imaging; MRI systems engineering

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Neil Hukriede, PhD Neil Hukriede, PhD
Email: hukriede@pitt.edu
Research Keywords:
Renal progenitor cells; kidney regeneration

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Annie Im, MD Annie Im, MD
Email: imap@upmc.edu
Research Keywords:
Hematologic malignancies; drug development; stem cell transplantation; graft-versus-host-disease

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Kabirul Islam, PhD Kabirul Islam, PhD
Email: kai27@pitt.edu
Research Keywords:
Epigenetics; small molecule therapeutics; chromatin-based proteomics and genomics; organic synthesis

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Rebecca Crowley Jacobson, MD, MS Rebecca Crowley Jacobson, MD, MS
Email: crowleyrs@upmc.edu
Research Keywords:
Medical decision making and decision support; clinical natural language processing and information extraction; multi-institution data and tissue sharing; personalized medicine; biomedical informatics; bioinformatics

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Yu Jiang, PhD Yu Jiang, PhD
Email: yuj5@pitt.edu
Research Keywords:
Protein kinases; protein phosphatases; tumor suppressors; mTOR; breast cancer; estrogen receptor; arachidonic acid; mitochondria

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Paul A. Johnston, PhD Paul A. Johnston, PhD
Email: paj18@pitt.edu
Research Keywords:
Prostate cancer; melanoma; head and neck cancer; squamous cell carcinoma; assay development; high throughput screening; high content screening; HTS; HCS; drug discovery

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Valerian Kagan, PhD, DSc Valerian Kagan, PhD, DSc
Email: kagan@pitt.edu
Research Keywords:
Free radical biochemistry; phospholipid signaling in cell death pathways; nitric oxide (NO) interactions with cellular components; antioxidant activity of pulmonary epithelial and endothelial proteins

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Kazunori Koide, PhD Kazunori Koide, PhD
Email: koide@pitt.edu
Research Keywords:
Organic synthesis of natural products; new synthetic methods; organic fluorescent sensors

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Eric Lagasse, PharmD, PhD Eric Lagasse, PharmD, PhD
Email: lagasse@pitt.edu
Research Keywords:
Cancer stem cells; colon cancer; ovarian cancer; head and neck cancer; liver cancer

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James J. Lee, MD, PhD James J. Lee, MD, PhD
Email: leejj@upmc.edu
Research Keywords:
Experimental therapeutics; phase I clinical trials; colorectal cancer

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Song Li, MD, PhD Song Li, MD, PhD
Email: sol4@pitt.edu
Research Keywords:
Targeted delivery of therapeutics; gene regulation

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Frank S. Lieberman, MD Frank S. Lieberman, MD
Email: liebermanf@upmc.edu
Research Keywords:
Neuro-oncology; molecular genetics and molecular neuropathology in diagnosis, prognosis, and management of CNS neoplasms

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Xinyu Liu, PhD Xinyu Liu, PhD
Email: xinyuliu@pitt.edu
Research Keywords:
Natural product biosynthesis; synthetic chemistry; drug discovery

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James Mountz, MD, PhD James Mountz, MD, PhD
Email: mountzjm@upmc.edu
Research Keywords:
Radiology; functional brain imaging; diagnostic PET-CT; quantitative biomarker imaging for early therapy response assessment in cancer

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Daniel Normolle, PhD Daniel Normolle, PhD
Email: dpn7@pitt.edu
Research Keywords:
Biostatistics; design of dose-escalation trials; biomarker adaptive clinical trials

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Patrick J. Pagano, PHD Patrick J. Pagano, PHD
Email: pagano@pitt.edu
Research Keywords:
NADPH oxidase (Nox); small molecule inhibitors

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Rahul Parikh, MD, PhD Rahul Parikh, MD, PhD
Email: parikhr@upmc.edu
Research Keywords:
Genito-urinary malignancies; prostate adenocarcinoma

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Ian Pollack, MD Ian Pollack, MD
Email: ian.pollack@chp.edu
Research Keywords:
Pediatric neurosurgery; pediatric neuro-oncology; brain tumor vaccines; craniofacial surgery; congenital spinal abnormalities; brain tumor clinical trials

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Daniel R. Premkumar, PhD Daniel R. Premkumar, PhD
Email: Daniel.Premkumar@chp.edu
Research Keywords:
Glioblastoma; signal transduction; targeted therapeutics

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Robert L. Redner, MD Robert L. Redner, MD
Email: redner@pitt.edu
Research Keywords:
Acute promyelocytic leukemia; acute myeloid leukemia; myelodysplastic syndromes; malignant and non-malignant hematology

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John Schmitz, PhD John Schmitz, PhD
Email: schmitzjc@upmc.edu
Research Keywords:
Signal transduction; colorectal cancer; herbal medicine

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Mark E. Schurdak, PhD Mark E. Schurdak, PhD
Email: mes234@pitt.edu
Research Keywords:
Systems biology; pharmacology; drug discovery; high-content screening

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Alison Sehgal, MD Alison Sehgal, MD
Email: sehgalar@upmc.edu
Research Keywords:
Acute leukemia; lymphoma; stem cell transplant

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Ronald Gary Stoller, MD Ronald Gary Stoller, MD
Email: stollerrg@upmc.edu
Research Keywords:
Gastro-malignancies; pancreatic carcinoma; abdominal carcinomatosis; general oncology

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Dandan Sun, MD, PhD Dandan Sun, MD, PhD
Email: dds30@pitt.edu
Research Keywords:
Glioblastoma; ion transporter proteins

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Weijing Sun, MD Weijing Sun, MD
Email: sunw@upmc.edu
Research Keywords:
GI malignancies; targeted therapeutics; clinical trials

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D. Lansing Taylor, PhD D. Lansing Taylor, PhD
Email: dltaylor@pitt.edu
Research Keywords:
Cellular and tissue systems biology; drug discovery; temporal-spatial dynamics of signaling molecules and proteins in living cells; cellular population dynamics

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Michael Tsang, PhD Michael Tsang, PhD
Email: tsang@pitt.edu
Research Keywords:
Fibroblast growth factor (FGF); signal transduction

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Andreas Vogt, PhD Andreas Vogt, PhD
Email: avogt@pitt.edu
Research Keywords:
Drug discovery; high-content screening; zebrafish; phenotypic assays; dual specificity phosphatase; breast cancer

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Qiming Wang, PhD Qiming Wang, PhD
Email: qjw1@pitt.edu
Research Keywords:
Signal transduction; protein kinases & phosphatases; structural pharmacology; cancer pharmacology; drug discovery

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Wen Xie, MD, PhD Wen Xie, MD, PhD
Email: wex6@pitt.edu
Research Keywords:
Drug metabolism; gene regulation; nuclear hormone receptors; breast cancer; prostate cancer; colon cancer; liver disease; metabolic syndrome

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Xiang-Qun Xie, PhD, MBA Xiang-Qun Xie, PhD, MBA
Email: xix15@pitt.edu
Research Keywords:
GPCR CB2 membrane protein; multiple myeloma; in silico drug design

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