University of Pittsburgh Cancer Institute (UPCI)

Early Phase Clinical Trials

Clinical TrialsClinical investigators in the CTP design and perform Phase I, Phase I/II, and Phase II studies of small molecule anticancer agents, either alone or in combination with other drugs.

Selected Publications

  • Imatinib mesylate (Gleevec(®)) has revolutionized the treatment of chronic myeloid leukemias and gastrointestinal stromal tumors, and there is evidence for an exposure response relationship. Calcium carbonate is increasingly used as a calcium supplement and in the setting of gastric upset associated with imatinib therapy. Because calcium carbonate could conceivably elevate gastric pH and complex imatinib, thereby influencing imatinib absorption and exposure, a clinical study was performed. It was determined that the use of calcium carbonate does not significantly affect imatinib pharmacokinetics. (Tawbi et. al., Cancer Chemother Pharmacol. 2014 Jan;73(1):207-11.)
  • Stereotactic body radiation therapy (SBRT) is a radiotherapy modality that delivers highly conformal, ablative doses to a well-defined target. Analysis of ATM and H2AX phosphorylation using a semiquantitative multiplexed assay showed that ATM kinase activity in peripheral blood mononuclear cells is induced following SBRT. This observation of a systemic ATM kinase-dependent DNA damage response in the peripheral blood is unprecedented and promotes the use of ATM serine-1981 phosphorylation as a predictive biomarker for DNA damaging modalities and ATM inhibitors. (Bakkenist et. al., Oncotarget. 2013 Aug;4(8):1143-8.)
  • The feasibility of administering carboplatin as a radiosensitizer during craniospinal radiation therapy (CSRT) to patients with high-risk medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumors was evaluated in a Phase I/II study. It was determined that the use of carboplatin as a radiosensitizer is a promising strategy for patients with metastatic MB. (Jakacki et. al., J Clin Oncol. 2012 Jul 20;30(21):2648-53.)

Members

Amankulor, Nduka, MD
Neurological Surgery
Mountz, James, MD, PhD
Radiology
Appleman, Leonard, MD, PhD
Medicine
Normolle, Daniel, PhD
Biostatistics
Bahary, Nathan, MD, PhD
Medicine
Pagano, Patrick, PhD
Pharmacology & Chemical Biology
Beumer, Jan-Hendrik, PharmD, PhD
Pharmaceutical Sciences
Parikh, Rahul, MD, PhD
Medicine
Boyiadzis, Michael, MD
Medicine
Pollack, Ian, MD
Neurological Surgery
Chu, Edward, MD
Medicine
Redner, Robert, MD
Medicine
Drappatz, Jan, MD
Neurology
Schmitz, John, PhD
Medicine
Im, Annie, MD
Medicine
Sehgal, Alison, MD
Medicine
Lee, James, MD, PhD
Medicine
Stoller, Ronald, MD
Medicine
Lieberman, Frank, MD
Neurology
Sun, Weijing, MD
Medicine
Liu, Xinyu, PhD
Chemistry