Optimization of Radiation Response
Radiation therapy is the major clinical approach for treating brain tumors. Clinical and translational initiatives are focused on examining strategies to optimize efficacy of radiation for these tumors.
- Surgical resection with gamma knife stereotactic radiosurgery (SRS) remains the primary approach for larger brain metastases if feasible, and tumor volume is a better indicator than maximum diameter. Tumor volume and edema responds better in patients who underwent SRS alone (Yang et.al., Neurosurgery. 2011, 68:682-90).
- Stereotactic radiosurgery for small-cell lung carcinoma brain metastases provides safe and effective local tumor control in the majority of patients (Wegner et.al., Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):e21-7).
- Stereotactic radiosurgery is an especially valuable option for patients with higher Karnofsky Performance status and smaller number of brain metastases from renal cell carcinoma (Kano et.al., Neurosurgery. 2011 Dec;69(6):1232-9).
|Flickinger, John, MD
|Lunsford, L. Dade, MD, FACS
|Grandi, Paola, PhD
|Niranjan, Ajay, MD