Modulation of Glioma Angiogenesis and Invasion by Pharmacological Interventions
This multidisciplinary group investigates molecular mechanisms of angiogenesis and invasiveness in CNS tumors, as well as possible therapeutic strategies to modulate this process.
- Some glioblastomas overexpress platelet-derived growth factor receptor α and promotes tumorigenesis through the PI3K/AKT/mTOR-mediated pathway regulated by SHP-2 activity. These findings functionally validate the genomic analysis of glioblastomas and identify SHP-2 as a potential target for treatment of glioblastomas (Liu et.al., J Clin Invest. 2011, 121:905-17).
- ZD6474, a dual inhibitor for vascular endothelial growth factor receptor 2 and epidermal growth factor receptor (EGFR) significantly inhibits growth and angiogenesis of gliomas expressing EGFRvIII by specifically blocking EGFRvIII-activated signaling mediators, suggesting a potential application of ZD6474 in treatments for glioblastomas that overexpress EGFRvIII (Yiin et.al., Mol Cancer Ther. 2010, 9:929-41).
|Lieberman, Frank, MD