Stress Effects on Cancer Development and Progression
Biobehavioral investigations of effects of psychological stress on biological processes involved in cancer etiology, progression, and treatment efficacy are a continuing focus of the BOP. One goal of the BOP is to increase appreciation of emerging cancer research demonstrating that pro-inflammatory processes contribute to the development and progression of several types of cancer, as well as emerging evidence of direct effects of neuroendocrine influences on pre-neoplastic and transformed cells themselves.
- The immune system is highly responsive to stress, although the complete mechanisms linking stress and immune mediators, including T lymphocytes, are not fully understood. BOP researchers show that stress, via release of stress hormones, induces early T cell activation and greatly impacts the cytoskeleton by modulating numerous actin-regulating proteins (Flint MS, et. al., Brain Behav Immun. 25:1187-96, 2011).
- BOP members examined the connections between emotional responses and increased levels of circulating inflammatory markers, using experimental induction of psychological stress with a speech task under controlled laboratory conditions. Results revealed positive associations between increases in IL-6 levels and task-related increases in anger and anxiety, which were independent of variability in participants' levels of cardiovascular reactivity to the task. (Carroll JE et.al. Brain Behav Immun. 25:232-8, 2011).
|Bovbjerg, Dana, PhD
|Steel, Jennifer, PhD
|Jenkins, Frank, PhD
|Rosenzweig, Margaret, PhD, CRNP-C, AOCN
|Perkins, Kenneth, PhD