University of Pittsburgh Cancer Institute (UPCI)

Charles Horn, PhD

Charles Horn
Associate Professor of Medicine and Anesthesiology


Contact Information

Contact Information

Hillman Cancer Center - Research Pavilion, G.17b
5117 Centre Avenue
Pittsburgh, PA 15213

Phone: 412-623-1417
Email: chorn@pitt.edu
Fax: 412-623-1119

Administrative Assistant
Name: Jessica Poli
Phone: 412-623-7701
Email: polij@upmc.edu
Fax: 412-623-1119

Research Keywords

Research Keywords

Chemotherapy side effects; nausea and vomiting; quality of life; neurobiology

Research Summary

Research Summary


Afferent signaling from the gastrointestinal tract can be disrupted by cancer chemotherapy.

Neural interactions between the alimentary tract and brain are essential to good health, but cancer patients often experience disrupted gastrointestinal (GI) function, reduced nutrition, and the symptoms of nausea and vomiting. My research focuses on determining the biological mechanisms that control gut-brain communication and contribute to nutritional homeostasis. Current interests include studies on the neurobiological mechanisms of nausea and vomiting. This research program has the long-term goal of developing novel therapies to decrease GI symptom burden and improve quality of life for cancer patients.

Selected Publications

Selected Publications

  • Horn CC, Wang H, Estival L, Meyers K, Magnusson M. Novel dynamic measures of emetic behavior in musk shrews. Auton Neurosci. 2013 Dec;179(1-2):60-7. PubMed Link
    Shared Resources Used: AF
  • Horn CC, Meyers K, Pak D, Nagy A, Apfel CC, Williams BA. Post-anesthesia vomiting: Impact of isoflurane and morphine on ferrets and musk shrews. Physiology and Behavior, 2012, 106:562-8. PubMed Link
    Shared Resources Used: AF
  • Horn CC, Henry S, Meyers K, Magnusson MS. Behavioral patterns associated with chemotherapy-induced emesis: A potential signature for nausea in musk shrews. Frontiers in Neuroscience. 2011. 5:88. PubMed Link
    Shared Resources Used: AF
  • Horn CC. The medical implications of gastrointestinal vagal afferent pathways in nausea and vomiting. Current Pharmaceutical Design. 2013, in press. PubMed Link
  • Horn CC, Wallisch WJ, Homanics GE, Williams JP. Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. European Journal of Pharmacology 2014 in press.
  • Huang D, Meyers K, Henry S, De la Torre F, Horn CC. Computerized detection and analysis of cancer chemotherapy-induced vomiting in a small animal model, musk shrew. Journal of Neuroscience Methods. 2011. 197:249-58. PubMed Link
    Shared Resources Used: AF
  • Horn CC, De Jonghe BC, Matyas K, Norgren R. Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat. Am J Physiol (Reg Comp Integr Physiol). 2009, 297:R1375-82. PubMed Link
  • Horn CC. Brain Fos expression induced by the chemotherapy agent cisplatin in the rat is partially dependent on an intact vagus. Auton Neurosci. 2009, 148(1-2):76-82. PubMed Link

See all pubs (Pubmed)

Collaborations

Collaborations

Current UPCI/Pitt Collaborators

Dana Bovbjerg, PhD
Visiting Professor of Psychiatry
Leader - Biobehavioral Oncology Program (BOP)
Member - Women's Cancer Research Center (WCRC)

Linda Rinaman, PhD
Professor of Neuroscience

Bill Yates, PhD
Professor of Otolaryngology and Neuroscience

Current External Collaborators

Paul Andrews, PhD
Emeritus Professor of Comparative Physiology
St. Georges University of London

UPCI Shared Resource Usage

UPCI Shared Resource Usage

  • Animal Facility
  • Biostatistics Facility
  • Cell and Tissue Imaging Facility

Affiliated Graduate Programs

Affiliated Graduate Programs

  • Center for Neuroscience

Department Website

Lab Website









Last modified: 6/2/14